Specific circulating microRNA signature of bicuspid aortic valve disease

Bicuspid aortic valve disease.

Bicuspid aortic valve (BAV) disease is the most common congenital cardiac defect. While the BAV can be found in isolation, it is often associated with other congenital cardiac lesions. The most frequent associated finding is dilation of the proximal ascending aorta secondary to abnormalities of the aortic media. Changes in the aortic media are present independent of whether the valve is functio...

Aortic dilatation in bicuspid aortic valve disease.

Bicuspid aortic valve (BAV) is the most common congenital cardiac abnormality, occurring in 0.5%-1.4% of the population; this anomaly is sporadically transmitted genetically by an autosomaldominant pathway, with a 3:1 male predominance. BAV is clinically important, not only because of valve-related complications (valve dysfunction, infective endocarditis), but also because of its association wi...

Genetics of Bicuspid Aortic Valve and Calcific Aortic Valve Disease

Surgical treatment of bicuspid aortic valve disease

Methods 1217 patients with BAV were treated in the Institute during 2003−2012. There were 902 (74.1%) males. Patients age ranged from 3 days to 76 years, mean 50.2 ± 9,8 years. Aneurysm of ascending aorta took place in 380 (31.2%) pts, 39 (10,3%) of them admitted with dissection. We use: balloon valvuloplasty in 82 (8.1%) patients. Different operative interventions were fulfilled to the rest :1...

MicroRNA Expression Signature in Human Calcific Aortic Valve Disease

Altered microRNA (miRNA, miR) expression has been related to many disease processes; however, the miRNA expression signature in calcific aortic valve disease (CAVD) is unclear. In this study, microarrays were used to determine the miRNA expression signature of tissue samples from healthy individuals (n = 4) and patients with CAVD (n = 4). TargetScan, PITA, and microRNAorg 3-way databases were u...